1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine

Base Information

• Chemical Name: 1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine
• CAS No.: 177948-41-3
• Molecular Formula: C₁₉H₂₉FN₂O₃
• Molecular Weight: 352.449
• Mol file: 177948-41-3.mol

Synonyms:1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine

Chemical Property of 1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine

There total 4 articles about 1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + (R)-1-(4-fluorophenyl)-2-(methoxy)ethylamine (321840-35-1) → 1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine (177948-41-3)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 72h;

DOI:10.1021/jm9910021

Reference yield:

(R)-2-(4-fluorophenyl)glycine (93939-74-3) → 1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine (177948-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 82 percent / LiAlH₄ / tetrahydrofuran / 0.27 h / 20 °C

2.1: KH / tetrahydrofuran / 2 h

2.2: tetrahydrofuran / 18 h

3.1: AcOH; NaCNBH₃ / methanol / 72 h / 20 °C

With lithium aluminium tetrahydride; potassium hydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; 1.1: Reduction / 2.1: Metallation / 2.2: Methylation / 3.1: reductive amination;

DOI:10.1021/jm9910021

Reference yield:

(R)-2-amino-2-(4-fluorophenyl)ethanol (174770-74-2) → 1-tert-Butyloxycarbonyl-4-[(R)-1-(4-fluorophenyl)-2-methoxyethyl]aminopiperidine (177948-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KH / tetrahydrofuran / 2 h

1.2: tetrahydrofuran / 18 h

2.1: AcOH; NaCNBH₃ / methanol / 72 h / 20 °C

With potassium hydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; 1.1: Metallation / 1.2: Methylation / 2.1: reductive amination;

DOI:10.1021/jm9910021

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

(R)-1-(4-fluorophenyl)-2-(methoxy)ethylamine

(R)-2-(4-fluorophenyl)glycine

(R)-2-amino-2-(4-fluorophenyl)ethanol