C₂₈H₃₄N₄O₅S₃

Base Information

• Chemical Name: C₂₈H₃₄N₄O₅S₃
• CAS No.: 1338230-01-5
• Molecular Formula: C₂₈H₃₄N₄O₅S₃
• Molecular Weight: 602.8
• Mol file: 1338230-01-5.mol

Synonyms:C₂₈H₃₄N₄O₅S₃

Chemical Property of C₂₈H₃₄N₄O₅S₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₄N₄O₅S₃

There total 13 articles about C₂₈H₃₄N₄O₅S₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(5R,8S,11S)-8-isopropyl-5-methyl-11-((E)-4-(tritylthio)but-1-en-1-yl)-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.12,5]icosa-1(18),2(20),16(19)-triene-6,9,13-trione (1043577-37-2) + salicylic alcohol (90-01-7) → C28H34N4O5S3 (1338230-01-5)

Guidance literature:

(5R,8S,11S)-8-isopropyl-5-methyl-11-((E)-4-(tritylthio)but-1-en-1-yl)-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.12,5]icosa-1⁽¹⁸⁾,2⁽²⁰⁾,16⁽¹⁹⁾-triene-6,9,13-trione; With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

salicylic alcohol; In dichloromethane;

DOI:10.1021/jm200432a

Reference yield:

(4R)-methyl 2-(2-((8S)-1-(9H-fluoren-9-yl)-5-isopropyl-3,6,10-trioxo-8-((E)-4-(tritylthio)-but-1-enyl)-2,7-dioxa-4,11-diazadodecan-12-yl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxylate (1092363-40-0) → C28H34N4O5S3 (1338230-01-5)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium hydroxide / tetrahydrofuran; water / 1.25 h / 0 °C

2: diethylamine / dichloromethane / 3 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 30 h / 20 °C

4: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; chlorotriisopropylsilane; diethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jm200432a

Reference yield:

C55H54N4O7S3 (1092363-38-6) → C28H34N4O5S3 (1338230-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: diethylamine / dichloromethane / 3 h / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 30 h / 20 °C

3: chlorotriisopropylsilane; trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; chlorotriisopropylsilane; diethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm200432a

upstream raw materials:

(R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxylic acid

(5R,8S,11S)-8-isopropyl-5-methyl-11-((E)-4-(tritylthio)but-1-en-1-yl)-10-oxa-3,17-dithia-7,14,19,20-tetraazatricyclo[14.2.1.12,5]icosa-1⁽¹⁸⁾,2⁽²⁰⁾,16⁽¹⁹⁾-triene-6,9,13-trione

salicylic alcohol

C₅₅H₅₄N₄O₇S₃