ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate

Base Information

Chemical Name:ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate
CAS No.:770712-00-0
Molecular Formula:C₂₀H₃₁NO₃
Molecular Weight:333.471
Hs Code.:

Synonyms:ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate

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Chemical Property of ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate

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Technology Process of ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate

There total 5 articles about ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 773070-58-9
ethyl {(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}acetate

: 3188-13-4
ethyl chloromethyl ether

: 770712-00-0
ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate

Guidance literature:: ethyl {(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

ethyl chloromethyl ether; In tetrahydrofuran; at -78 - 20 ℃; for 16h;
DOI:10.1039/b406632d

Reference yield:

: 5259-98-3
5-chloropentan-1-ol

: 770712-00-0
ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 45 percent / Et₃N / ethanol / 16 h / Heating

2.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 94 percent / tetrahydrofuran / 16 h / -78 - 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; 1.1: Swern oxidation / 2.1: Horner-Wadsworth-Emmons reaction / 3.1: Finkelstein reaction;
DOI:10.1039/b406632d

Reference yield:

: 20074-80-0
5-chloro-pentanal

: 770712-00-0
ethyl (2R)-3-ethoxy-2-{(2S)-1-[(1R)-1-phenylethyl]piperidin-2-yl}propionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 45 percent / Et₃N / ethanol / 16 h / Heating

2.1: LHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 94 percent / tetrahydrofuran / 16 h / -78 - 20 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; 1.1: Horner-Wadsworth-Emmons reaction / 2.1: Finkelstein reaction;
DOI:10.1039/b406632d