Technology Process of 3-Pyridinecarboxylic acid, 2-amino-, 1-oxide
There total 3 articles about 3-Pyridinecarboxylic acid, 2-amino-, 1-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-aminonicotinic acid methyl ester N-oxide;
With
sodium hydroxide;
In
methanol;
for 1h;
Reflux;
With
hydrogenchloride;
In
water;
at 0 ℃;
pH=4-5;
DOI:10.1021/jm401249c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / Reflux
1.2: 18 h / 20 °C / Reflux
2.1: methyltrioxorhenium(VII); dihydrogen peroxide / ethanol; water / 3 h / 20 °C
3.1: sodium hydroxide; water / ethanol / 10 h / Reflux
With
water; dihydrogen peroxide; methyltrioxorhenium(VII); potassium carbonate; sodium hydroxide;
In
ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methyltrioxorhenium(VII); dihydrogen peroxide / ethanol; water / 3 h / 20 °C
2: sodium hydroxide; water / ethanol / 10 h / Reflux
With
water; dihydrogen peroxide; methyltrioxorhenium(VII); sodium hydroxide;
In
ethanol; water;
