methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

Base Information

Chemical Name:methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside
CAS No.:262301-25-7
Molecular Formula:C₄₁H₄₆O₁₀S
Molecular Weight:730.876
Hs Code.:

Synonyms:methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

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Chemical Property of methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

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Technology Process of methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

There total 5 articles about methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 262301-24-6
methyl 2,3-di-O-acetyl-6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

: 262301-25-7
methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

Guidance literature:: With sodium methylate; In methanol; at 20 ℃;
DOI:10.1021/jo9914667

Reference yield:

: 262301-23-5
methyl 2,3-di-O-acetyl-6-O-benzyl-4-thio-α-D-glucopyranoside

: 262301-25-7
methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / DTBMP; Tf₂O / CH₂Cl₂ / 2.5 h / -78 - 0 °C

2: 57 percent / NaOMe / methanol / 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; sodium methylate; In methanol; dichloromethane; 1: Substitution / 2: Deacetylation;
DOI:10.1021/jo9914667

Reference yield:

: methyl 2,3-di-O-acetyl-6-O-benzyl-α-D-galactopyranoside

: 262301-25-7
methyl 6-O-benzyl-4-S-(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-4-thio-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / I₂; PPh₃; imidazole / tetrahydrofuran

2: 66 percent / dimethylformamide / 2 h / 90 °C

3: 65 percent / N₂H₄*H₂O; CH₃CO₂H / dimethylformamide / 0.33 h

4: 63 percent / DTBMP; Tf₂O / CH₂Cl₂ / 2.5 h / -78 - 0 °C

5: 57 percent / NaOMe / methanol / 20 °C

With 1H-imidazole; 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; iodine; sodium methylate; hydrazine hydrate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Iodination / 2: Acetylation / 3: Deacetylation / 4: Substitution / 5: Deacetylation;
DOI:10.1021/jo9914667