(S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.:1321589-33-6
Molecular Formula:C₂₀H₂₇NO₃
Molecular Weight:329.439
Hs Code.:

Synonyms:(S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

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Chemical Property of (S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

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Technology Process of (S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

There total 4 articles about (S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1321589-08-5
(S)-tert-butyl 2-methyl-6-oxo-8-phenyloct-7-yn-4-ylcarbamate

: 1321589-33-6
(S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With silver hexafluoroantimonate; (triphenylphosphine)gold(I) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 1h; optical yield given as %ee; enantiospecific reaction; Inert atmosphere;
DOI:10.1021/ol201698m

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 1321589-33-6
(S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; isobutyl chloroformate / tetrahydrofuran

2: silver nitrate; triethylamine / tetrahydrofuran

3: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4: (triphenylphosphine)gold(I) chloride; silver hexafluoroantimonate / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

With silver hexafluoroantimonate; n-butyllithium; (triphenylphosphine)gold(I) chloride; silver nitrate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; hexane; 1,2-dichloro-ethane; 1: Arndt-Eistert synthesis / 1: Arndt-Eistert synthesis;
DOI:10.1021/ol201698m

Reference yield:

: 52716-48-0
(3S)-3-<(tert-butoxy)carbonylamino>-1-diazo-5-methylhexan-2-one

: 1321589-33-6
(S)-tert-butyl 2-isobutyl-4-oxo-6-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: silver nitrate; triethylamine / tetrahydrofuran

2: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3: (triphenylphosphine)gold(I) chloride; silver hexafluoroantimonate / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

With silver hexafluoroantimonate; n-butyllithium; (triphenylphosphine)gold(I) chloride; silver nitrate; triethylamine; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;
DOI:10.1021/ol201698m