3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin

Base Information

• Chemical Name: 3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin
• CAS No.: 1093856-94-0
• Molecular Formula: C₄₆H₇₃NO₁₃
• Molecular Weight: 848.085

Synonyms:3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin

Chemical Property of 3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin

Chemical Property:

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Technology Process of 3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin

There total 1 articles about 3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-desmethylclarithromycin (101666-68-6) + (4-ethynylphenyl)methyl methanesulfonate → 3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin (1093856-94-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 85 ℃; for 2h;

DOI:10.1021/jm100507q

Reference yield: 99.0%

C22H30N4O2Si (1099646-80-6) + 3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin (1093856-94-0) → C68H103N5O15Si (1099646-81-7)

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm801128g

Reference yield: 81.0%

3'-N-(desmethyl)-3'-N-(4-ethynylbenzyl)clarithromycin (1093856-94-0) + acetic anhydride (108-24-7) → ((3'-O-acetyl)-4'-N-(4-ethynylbenzyl))clarithromycin

Guidance literature:

In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.bmc.2015.10.045

upstream raw materials:

N-desmethylclarithromycin

Downstream raw materials:

C₆₈H₁₀₃N₅O₁₅Si

C₅₂H₈₅N₅O₁₅

C₅₃H₈₇N₅O₁₅

C₅₄H₈₉N₅O₁₅

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