1-[2-(Benzyloxy)ethyl]-cyclohexanecarboxylic Acid Methyl Ester

Base Information

• Chemical Name: 1-[2-(Benzyloxy)ethyl]-cyclohexanecarboxylic Acid Methyl Ester
• CAS No.: 865459-93-4
• Molecular Formula: C₁₇H₂₄O₃
• Molecular Weight: 276.376
• Mol file: 865459-93-4.mol

Synonyms:C₁₇H₂₄O₃

Chemical Property of 1-[2-(Benzyloxy)ethyl]-cyclohexanecarboxylic Acid Methyl Ester

Chemical Property:

• Solubility.: Dichloromethane

Purity/Quality:

98% ^*data from raw suppliers

1-[2-(Benzyloxy)ethyl]-cyclohexanecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-[2-(Benzyloxy)ethyl]-cyclohexanecarboxylic Acid Methyl Ester can be used in the preparation of peptidyl sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease.

Technology Process of 1-[2-(Benzyloxy)ethyl]-cyclohexanecarboxylic Acid Methyl Ester

There total 3 articles about 1-[2-(Benzyloxy)ethyl]-cyclohexanecarboxylic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methyl cyclohexylcarboxylate (4630-82-4) + benzyl iodoethyl ether (54555-84-9) → C17H24O3 (865459-93-4)

Guidance literature:

methyl cyclohexylcarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at 0 ℃; for 0.25h; Reflux;

benzyl iodoethyl ether; In tetrahydrofuran; hexane; for 3h; Reflux;

DOI:10.1002/anie.201807097

Reference yield:

methyl cyclohexylcarboxylate (4630-82-4) + bromoethyl-2-benzyl ether (1462-37-9) → C17H24O3 (865459-93-4)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; toluene;

Reference yield:

bromoethyl-2-benzyl ether (1462-37-9) → C17H24O3 (865459-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium iodide / acetone / Reflux

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.25 h / 0 °C / Reflux

2.2: 3 h / Reflux

With n-butyllithium; diisopropylamine; sodium iodide; In tetrahydrofuran; hexane; acetone;

DOI:10.1002/anie.201807097

upstream raw materials:

methyl cyclohexylcarboxylate

bromoethyl-2-benzyl ether

benzyl iodoethyl ether

Downstream raw materials:

C₁₀H₁₈O₃

2-oxaspiro[4.5]decan-1-one

Refernces

• 1、 -. "SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE". Page/Page column 132. . Retrieved 2010/02/14.