(3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

Base Information

Chemical Name:(3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol
CAS No.:1142231-87-5
Molecular Formula:C₂₀H₂₄FNO₂
Molecular Weight:329.414
Hs Code.:

Synonyms:(3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

Suppliers and Price of (3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

There total 14 articles about (3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1222091-38-4
methyl 3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)benzoate

: 1142231-87-5
(3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

Guidance literature:: methyl 3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)benzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; Ice bath;

With water; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 1142225-01-1
(3-(5,5-dimethylcyclopent-1-enyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

: 1142231-87-5
(3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

: 1142231-86-4
(3-((S)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 2 h / Inert atmosphere

2: chiral OD column / hexane; isopropyl alcohol / Resolution of racemate; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In methanol; hexane; ethyl acetate; isopropyl alcohol;
DOI:10.1021/ml300427u

Reference yield:

: 1142225-00-0
methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(5-fluoro-2-methoxypyridin-4-yl)benzoate

: 1142231-87-5
(3-((R)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

: 1142231-86-4
(3-((S)-2,2-dimethylcyclopentyl)-4-(5-fluoro-2-methoxypyridin-4-yl)phenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 2 h / Inert atmosphere

3: chiral OD column / hexane; isopropyl alcohol / Resolution of racemate; Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; hexane; ethyl acetate; isopropyl alcohol;
DOI:10.1021/ml300427u