2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide

Base Information

Chemical Name:2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide
CAS No.:1403883-52-2
Molecular Formula:C₂₀H₁₅F₅N₂O₄S
Molecular Weight:474.408
Hs Code.:

Synonyms:2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide

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Chemical Property of 2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide

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Technology Process of 2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide

There total 6 articles about 2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1403880-91-0
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

: 5188-07-8
sodium thiomethoxide

: 1403883-52-2
2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide

Guidance literature:: In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403883-52-2
2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 2 h / 130 °C

2: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3: triethylamine / dichloromethane / 20 °C / Cooling with ice

4: N-Bromosuccinimide; acetic acid / 20 °C

5: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

6: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7: potassium carbonate / methanol / 1 h / 20 °C

8: N,N-dimethyl-formamide / 1 h / 0 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; triethylamine; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1403883-97-5
2-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate

: 1403883-52-2
2,6-difluoro-3-(2-hydroxy-1-(5-(methylthio)-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid / 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 1 h / 20 °C

5: N,N-dimethyl-formamide / 1 h / 0 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; In methanol; tetrachloromethane; N,N-dimethyl-formamide;