2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

Base Information

Chemical Name:2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid
CAS No.:142843-23-0
Molecular Formula:C₃₂H₄₇N₅O₇S
Molecular Weight:645.82
Hs Code.:

Synonyms:2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

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Chemical Property of 2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

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Technology Process of 2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

There total 5 articles about 2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142843-15-0
ethyl 2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-N^im-Boc-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetate

: 142843-26-3
(5S,6R)-5-(cyclohexylmethyl)-6-hydroxy-4,5,6,7-tetrahydro-1,4-thiazepin-3(2H)-one

: 142843-23-0
2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

: 142843-24-1
2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In ethanol; for 3h; Ambient temperature;
DOI:10.1021/jm00093a009

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 142843-23-0
2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / triethylamine / ethanol

2: ethanolic HCl / 1 h / Ambient temperature

3: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

4: 53 percent / K₂CO₃ / ethanol / 3 h / Ambient temperature

With hydrogenchloride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00093a009

Reference yield:

: ((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butylsulfanyl)-acetic acid ethyl ester

: 142843-23-0
2-<<(2R,3S)-3-<(Boc-L-phenylalanyl-L-histidyl)amino>-4-cyclohexyl-2-hydroxy-1-butyl>thio>acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 17 h / Ambient temperature

2: 53 percent / K₂CO₃ / ethanol / 3 h / Ambient temperature

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm00093a009