ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate

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Chemical Name:ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate
CAS No.:1447966-47-3
Molecular Formula:C₂₃H₂₁N₃O₄S
Molecular Weight:435.503
Hs Code.:

Synonyms:ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate

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Chemical Property of ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate

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Technology Process of ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate

There total 5 articles about ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 622-52-6
p-methylphenylthiourea

: 1447966-39-3
ethyl 3-bromo-5-(1,3-dioxoisoindolin-2-yl)-4-oxopentanoate

: 1447966-47-3
ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate

Guidance literature:: With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 60 ℃; for 5h;
DOI:10.1016/j.tet.2013.06.060

Reference yield:

: 1074-82-4
potassium phtalimide

: 1447966-47-3
ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Br⁺

1.2: 20 °C / Cooling with ice

2.1: 1-butyl-3-methylimidazolium Tetrafluoroborate; hydrogen bromide; bromine / diethyl ether / 0.5 h / Reflux

3.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 5 h / 60 °C

With hydrogen bromide; bromine; 1-butyl-3-methylimidazolium Tetrafluoroborate; In diethyl ether; 3.1: |Hantzsch Thiazole Synthesis;
DOI:10.1016/j.tet.2013.06.060

Reference yield:

: 65706-98-1
ethyl 5-(1,3-dioxoisoindolin-2-yl)-4-oxopentanoate

: 1447966-47-3
ethyl 2-{4-[(1,3-dioxoisoindolin-2-yl)methyl]-2-[(4-methylphenyl)amino]thiazol-5-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-butyl-3-methylimidazolium Tetrafluoroborate; hydrogen bromide; bromine / diethyl ether / 0.5 h / Reflux

2: 1-butyl-3-methylimidazolium Tetrafluoroborate / 5 h / 60 °C

With hydrogen bromide; bromine; 1-butyl-3-methylimidazolium Tetrafluoroborate; In diethyl ether; 2: |Hantzsch Thiazole Synthesis;
DOI:10.1016/j.tet.2013.06.060