(E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate

Base Information

Chemical Name:(E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate
CAS No.:953434-81-6
Molecular Formula:C₃₁H₃₁N₃O₅S
Molecular Weight:557.67
Hs Code.:

Synonyms:(E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate

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Chemical Property of (E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate

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Technology Process of (E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate

There total 1 articles about (E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 335255-43-1
tert-butyl 2-amino-4-(thiophen-2-yl)phenylcarbamate

: 953434-80-5
(E)-3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylic acid compound with 2,2,2-trifluoroacetic acid (1:1)

: 953434-81-6
(E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate

Guidance literature:: With pyridine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; at 20 ℃; for 18h;

Reference yield: 54.0%

: 953434-81-6
(E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate

: (E)-N-(2-amino-5-(thiophen-2-yl)phenyl)-3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamide

Guidance literature:: (E)-tert-butyl 2-(3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)acrylamido)-4-(thiophen-2-yl)phenylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; ethyl acetate;