(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate
CAS No.:1558057-72-9
Molecular Formula:C₂₃H₂₉ClN₂O₃
Molecular Weight:416.948
Hs Code.:

Synonyms:(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

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Chemical Property of (2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

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Technology Process of (2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

There total 12 articles about (2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1558057-55-8
4-methoxybenzyl ((1R,2R)-1-((tert-butyldimethylsilyl)oxy)-1-(3-chlorophenyl)-6-(4-nitrophenyl)-5-oxohexan-2-yl)carbamate

: 1558057-72-9
(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 0 - 25 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 °C / Inert atmosphere

4: hydrogen; palladium 10% on activated carbon / methanol / 12 h

5: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Heating

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm4017224

Reference yield:

: 1558057-62-7
(2R,5S)-2-((R)-((tert-butyldimethylsilyl)oxy)(3-chlorophenyl)methyl)-5-(4-nitrobenzyl)pyrrolidine

: 1558057-72-9
(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 12 h

3: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Heating

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm4017224

Reference yield:

: 1558057-68-3
(2S,5S)-tert-butyl 2-((R)-((tert-butyldimethylsilyl)oxy)(3-chlorophenyl)methyl)-5-(4-nitrobenzyl)pyrrolidine-1-carboxylate

: 1558057-72-9
(2S,5R)-tert-butyl 2-(4-aminobenzyl)-5-((R)-(3-chlorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 12 h

2: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere; Heating

With palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; In tetrahydrofuran; methanol;
DOI:10.1021/jm4017224