6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine

Base Information

Chemical Name:6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine
CAS No.:131132-19-9
Molecular Formula:C₂₆H₂₃ClN₄O₅
Molecular Weight:509.922
Hs Code.:

Synonyms:6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine

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Technology Process of 6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine

There total 7 articles about 6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 131132-13-3
1,2,2'-trideuterio-3,5-di-O-p-toluoyl-β-2-deoxyribosyl chloride

: 87-42-3
6-chloropurine

: 131132-19-9
6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine

Guidance literature:: With sodium hydride; In acetonitrile; for 4h;
DOI:10.1021/jo00004a040

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 131132-19-9
6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 4-dimethylaminopyridine / pyridine / 2 h / 40 °C

2: 83 percent / HCl, HOAc

3: 60 percent / NaH / acetonitrile / 4 h

With hydrogenchloride; dmap; sodium hydride; acetic acid; In pyridine; acetonitrile;
DOI:10.1021/jo00004a040

Reference yield:

: 131132-17-7
2,2'-dideuterio-2-deoxyribonolactone

: 131132-19-9
6-chloro-9-(1',2',2''-trideuterio-3',5'-di-O-p-toluoyl-2'-deoxyribosyl)purine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / pyridine / tetrahydrofuran / 8 h

2: 82 percent / diisobutylaluminium deuteride (Dibal-D) / hexane; diethyl ether; CH₂Cl₂ / 2 h / -78 °C

3: 1.) HCl, Ag₂CO₃, 2.) tetra-n-butylammonium fluoride / 1.) 15 min, room temp., 2.) 30 min, room temp., THF

4: 95 percent / 4-dimethylaminopyridine / pyridine / 2 h / 40 °C

5: 83 percent / HCl, HOAc

6: 60 percent / NaH / acetonitrile / 4 h

With pyridine; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; diisobutylaluminium deuteride; sodium hydride; acetic acid; silver carbonate; In tetrahydrofuran; pyridine; diethyl ether; hexane; dichloromethane; acetonitrile;
DOI:10.1021/jo00004a040