Pic(3-OBzl)-Thr-OH

Base Information

• Chemical Name: Pic(3-OBzl)-Thr-OH
• CAS No.: 102410-53-7
• Molecular Formula: C₁₇H₁₈N₂O₅
• Molecular Weight: 330.34
• Mol file: 102410-53-7.mol

Synonyms:Pic(3-OBzl)-Thr-OH

Chemical Property of Pic(3-OBzl)-Thr-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pic(3-OBzl)-Thr-OH

There total 3 articles about Pic(3-OBzl)-Thr-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Pic(3-OBzl)-Thr-OMe (102410-47-9) → Pic(3-OBzl)-Thr-OH (102410-53-7)

Guidance literature:

With sodium hydroxide; In ethanol; for 4h; Ambient temperature;

DOI:10.1002/jlac.198619860101

Reference yield:

Pic(3-OBzl)-ONp (2900-16-5) → Pic(3-OBzl)-Thr-OH (102410-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 9 percent / (C₂H₅)3N / dimethylformamide / 40 h / Ambient temperature

2: 100 percent / 1 N NaOH / ethanol / 4 h / Ambient temperature

With sodium hydroxide; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jlac.198619860101

Reference yield:

Pic(3-OBzl)-OH*HCl (5603-02-1) → Pic(3-OBzl)-Thr-OH (102410-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / EDCI, NMM / CH₂Cl₂ / 1.) 4 h, -15 deg C to room temp., 2.) 2 d, room temp.

2: 100 percent / 1 N NaOH / ethanol / 4 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;

DOI:10.1002/jlac.198619860101

upstream raw materials:

Pic(3-OBzl)-Thr-OMe

Pic(3-OBzl)-ONp

Pic(3-OBzl)-OH*HCl

Downstream raw materials:

Pic(3-OBzl)-Thr(H-Phg)-D-Abu-Pro-OBu^t

Pic(3-OBzl)-Thr(H-MePhe-4Kps-Phg-)-D-Abu-Pro-OH*2HCl

Pic(3-OBzl)-Thr(Boc-MePhe-4Kps-Phg-)-D-Abu-Pro-OBu^t

Pic(3-OBzl)-Thr(H-Phg)-D-Abu-Pro-OBu^t*TFA