N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide

Base Information

• Chemical Name: N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide
• CAS No.: 1444023-83-9
• Molecular Formula: C₂₄H₂₅NO₃
• Molecular Weight: 375.467
• Mol file: 1444023-83-9.mol

Synonyms:N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide

Chemical Property of N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide

There total 1 articles about N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

p-benzyloxybenzaldehyde (4397-53-9) + N-(4-bromophenyl)isobutyramide (7160-08-9) → N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide (1444023-83-9)

Guidance literature:

N-(4-bromophenyl)isobutyramide; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.166667h; Inert atmosphere;

p-benzyloxybenzaldehyde; In tetrahydrofuran; hexane; at -50 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.05.012

Reference yield: 95.0%

N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide (1444023-83-9) → N-(4-(4'-(benzyloxy)benzoyl)phenyl)isobutyramide (1444023-98-6)

Guidance literature:

With Jones reagent; In acetone; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.05.012

Reference yield:

N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)isobutyramide (1444023-83-9) → (Z)-N-(4-(1',2'-bis(4'',4'''-hydroxyphenyl)-but-1'-enyl) phenyl)isobutyramide (1444024-67-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Jones reagent / acetone / 0.5 h / 0 °C / Inert atmosphere

2: zinc; titanium tetrachloride / tetrahydrofuran / 2.5 h / 0 °C / Inert atmosphere; Reflux

3: boron tribromide / dichloromethane / 1 h / -78 °C / Inert atmosphere

With Jones reagent; boron tribromide; titanium tetrachloride; zinc; In tetrahydrofuran; dichloromethane; acetone; 2: |McMurry Reaction;

DOI:10.1016/j.bmc.2013.05.012

upstream raw materials:

p-benzyloxybenzaldehyde

N-(4-bromophenyl)isobutyramide

Downstream raw materials:

(E)-N-(4-(1',2'-bis(4'',4'''-(benzyloxy)phenyl)but-1'-enyl)phenyl)isobutyramide

(E)-N-(4-(1',2'-bis(4'',4'''-hydroxyphenyl)-but-1'-enyl)phenyl)hexanamide

(Z)-N-(4-(1',2'-bis(4'',4'''-hydroxyphenyl)-but-1'-enyl) phenyl)isobutyramide

N-(4-(4'-(benzyloxy)benzoyl)phenyl)isobutyramide