dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)

Base Information

Chemical Name:dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)
CAS No.:1234369-93-7
Molecular Formula:C₂₆H₂₈N₆O₈
Molecular Weight:552.544
Hs Code.:

Synonyms:dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)

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Chemical Property of dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)

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Technology Process of dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)

There total 1 articles about dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 203798-34-9
3,6-diaminopyrazine-2,5-dicarboxylic acid

: 60022-62-0,879278-55-4,151651-44-4
D-serine benzyl ester hydrochloride

: 1234369-93-7
dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)

Guidance literature:: 3,6-diaminopyrazine-2,5-dicarboxylic acid; D-serine benzyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere; Cooling with ice;

With benzotriazol-1-ol; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere; Cooling with ice;

With ethylene dichloride hydrochloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 14h; Inert atmosphere; Cooling with ice;
DOI:10.1021/jm200257k

Reference yield: 78.0%

: 1234369-93-7
dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)

: 123-38-6
propionaldehyde

: 1313706-18-1
N₂,N₅-bis[(R)-1-(benzyloxy)-3-hydroxy-1-oxopropan-2-yl]-3,6-bis(propylamino)pyrazine-2,5-dicarboxamide

Guidance literature:: dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate); propionaldehyde; With acetic acid; In 1,2-dichloro-ethane; at 0 ℃; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm200257k

Reference yield: 47.0%

: 1234369-95-9
2,5,8,11,14,17,20,23-octaoxahexacosan-26-al

: 1234369-93-7
dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate)

: 1234369-96-0
3,6-bis(2,5,8,11,14,17,20,23-octaoxahexacosan-26-ylamino)-N₂,N₅-bis[(1R)-1-(benzyloxy)-3-hydroxy-1-oxopropan-2-yl]pyrazine-2,5-dicarboxamide

Guidance literature:: 2,5,8,11,14,17,20,23-octaoxahexacosan-26-al; dibenzyl 2,2’-((3,6-diaminopyrazine-2,5-dicarbonyl)bis(azanediyl))(2R,2’R)-bis(3-hydroxypropanoate); With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 168h; Inert atmosphere;

With sodium hydrogencarbonate; In 1,2-dichloro-ethane; for 0.5h;