2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide

Base Information

• Chemical Name: 2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide
• CAS No.: 111916-56-4
• Molecular Formula: C₁₂H₁₃NO₃S
• Molecular Weight: 251.306
• Mol file: 111916-56-4.mol

Synonyms:2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide

Chemical Property of 2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide

There total 1 articles about 2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

3,4-dibromosulfolane (7311-84-4,15091-30-2,125392-77-0) + C-phenyl-N-methylnitrone (3376-23-6,7372-59-0,59862-60-1) → 2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide (111916-56-4) + 2,6-dimethyl-3β,5α-diphenyl-2,3α,3aβ,4aα,5β,6,7aα,7bβ-octahydrothieno<2,3-d:5,4-d'>diisoxazole-4,4-dioxide (111916-62-2)

Guidance literature:

With pyridine; In toluene; for 24h; Heating;

DOI:10.1016/S0040-4020(01)82047-0

Reference yield: 62.0%

2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide (111916-56-4) → 4β-phenyl-4aβ,7aβ-dihydro-2H-thieno<2,3-d>-1,3-oxazin-3(4H)-ol-5,5-dioxide (111916-58-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 6h;

DOI:10.1016/S0040-4020(01)82047-0

Reference yield:

2-methyl-3β-phenyl-2,3α,3aβ,6aβ-tetrahydrothieno<2,3-d>isoxazole-4,4-dioxide (111916-56-4) → 5β-phenyl-8-thia-6-azatricyclo<3.2.1>octan-2α-ol (111916-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 6 h / 0 °C

2: 90.3 percent / toluene; 2-methyl-propan-2-ol / 16 h / Heating

3: 41 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

With lithium aluminium tetrahydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol;

DOI:10.1016/S0040-4020(01)82047-0

upstream raw materials:

3,4-dibromosulfolane

C-phenyl-N-methylnitrone

Downstream raw materials:

4β-phenyl-4aβ,7aβ-dihydro-2H-thieno<2,3-d>-1,3-oxazin-3(4H)-ol-5,5-dioxide

5β-phenyl-8-thia-6-azatricyclo<3.2.1>octan-2α-ol

5β-phenyl-8-thia-6-azatricyclo<3.2.1>octan-3α-d-2α-ol

9β-phenyl-2-oxa-6-thia-1-azatricyclo<3.3.1.0^3,7>nonan-4α-ol-6,6-dioxide