2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt
CAS No.:900175-00-0
Molecular Formula:C₂HF₃O₂*C₂₂H₂₄N₂O₅
Molecular Weight:510.467
Hs Code.:

Synonyms:2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt

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Chemical Property of 2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt

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Technology Process of 2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt

There total 1 articles about 2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 900174-98-3
benzyl 2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetate trifluoroacetic acid salt

: 900175-00-0
2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; for 5h; under 2585.81 - 3102.97 Torr;

Reference yield: 22.0%

: 900175-00-0
2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt

: 76-05-1
trifluoroacetic acid

: methyl 3-((R)-1-((R)-2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate trifluoroacetic acid salt

: methyl 3-((R)-1-((S)-2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate trifluoroacetic acid salt

Guidance literature:: (R)-methyl (4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)carbamate hydrochloride; 2-(1-aminoisoquinolin-6-yloxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid trifluoroacetic acid salt; With 1-hydroxy-7-aza-benzotriazole; N,N-diisopropylmethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 2h;

trifluoroacetic acid; In methanol; water;