Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine

Base Information

Chemical Name:Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine
CAS No.:1349848-59-4
Molecular Formula:C₃₂H₂₁F₅N₄O₂Zn
Molecular Weight:653.926
Hs Code.:

Synonyms:Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine

Suppliers and Price of Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine

There total 10 articles about Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3-(1-hydroxyethyl)-18,18-dimethyl-10-(pentafluorophenyl)-13-oxophorbine

: 1349848-59-4
Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine

Guidance literature:: With zinc diacetate; In methanol; chloroform; at 20 ℃; for 8h;
DOI:10.1039/c1nj20611g

Reference yield: 80.0%

: 3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13⁽¹⁾-oxophorbine

: 5970-45-6
zinc(II) acetate dihydrate

: 1349848-59-4
zinc(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13⁽¹⁾-oxophorbine

Guidance literature:: In methanol; chloroform; ligand in CHCl3 treated with Zn acetate in MeOH; stirred at room temp. for 8 h; diluted with ethyl acetate-MeOH; org. phase washed (satd. aq. NaHCO3, H2O, brine); concd.; freeze dried overnight; solid treated with Et2O; sonicated; centrifuged; supernatant removed; procedure beginning from Et2O treatment repeated two times;
DOI:10.1039/c1nj20611g

Reference yield:

: 892861-52-8
8-bromo-2,3,4,5-tetrahydro-1,3,3-trimethyldipyrrin

: 1349848-59-4
Zn(II)-3-(1-hydroxyethyl)-10-(pentafluorophenyl)-18,18-dimethyl-13'-oxophorbine

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / methanol; dichloromethane / 0.67 h / 20 °C / Inert atmosphere

1.2: 18 h / Reflux

1.3: 2 h

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; acetonitrile / 3.5 h / 83 °C / Inert atmosphere

3.1: hydrogenchloride; water / 0.33 h / 20 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / dichloromethane; trifluoroacetic acid / 1.5 h / 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / tetrahydrofuran / 4 h / 85 °C / Inert atmosphere

6.1: borane tert-butylamine / chloroform / 4 h / 20 °C / Inert atmosphere

6.2: 0.33 h / Inert atmosphere

7.1: zinc diacetate / methanol; chloroform / 8 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; zinc diacetate; water; borane tert-butylamine; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid; 2.1: Stille coupling;
DOI:10.1039/c1nj20611g