4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

Base Information

Chemical Name:4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide
CAS No.:1569880-30-3
Molecular Formula:C₁₉H₁₄F₆N₄O₂S₂
Molecular Weight:508.468
Hs Code.:

Synonyms:4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

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Chemical Property of 4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

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Technology Process of 4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

There total 3 articles about 4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1569880-03-0
C₁₇H₁₂ClF₆NO₂

: 2349-67-9
2-Amino-5-mercapto-1,3,4-thiadiazole

: 1569880-30-3
4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

Guidance literature:: 2-Amino-5-mercapto-1,3,4-thiadiazole; With sodium hydroxide; In ethanol; water; at 20 ℃; for 0.5h;

C₁₇H₁₂ClF₆NO₂; In ethanol; water; Reflux;
DOI:10.1248/cpb.c13-00242

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 1569880-30-3
4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C / Reflux

2.1: sodium hydroxide / ethanol; water / 0.5 h / 20 °C

2.2: Reflux

With triethylamine; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1248/cpb.c13-00242

Reference yield:

: 722-92-9
2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1569880-30-3
4-((5-amino-1,3,4-thiadiazol-2-ylthio)methyl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C / Reflux

2.1: sodium hydroxide / ethanol; water / 0.5 h / 20 °C

2.2: Reflux

With triethylamine; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1248/cpb.c13-00242