(1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

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Chemical Name:(1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene
CAS No.:627461-25-0
Molecular Formula:C₄₆H₇₈O₄Si₂
Molecular Weight:751.294
Hs Code.:

(1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Synonyms:(1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

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Chemical Property of (1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

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Technology Process of (1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

There total 7 articles about (1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 627461-24-9
(1S,3aR,7aR)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-octahydro-inden-4-one

: C₃₉H₆₃O₃PSi₂

: 627461-25-0
(1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -40 ℃;
DOI:10.1021/ol0351246

Reference yield:

: 17869-83-9
3-methoxymethoxy-3-methyl-but-1-yne

: 627461-25-0
(1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / CuI; pyrrolidine / 1 h / 20 °C

2.1: HF / 2 h / 20 °C

2.2: 99 percent / pyridinium dichromate / CH₂Cl₂ / 4 h / 20 °C

3.1: 80 percent / n-BuLi / hexane; tetrahydrofuran / -78 - -40 °C

With pyrrolidine; copper(l) iodide; n-butyllithium; hydrogen fluoride; In tetrahydrofuran; hexane; 3.1: Wittig-Horner coupling;
DOI:10.1021/ol0351246

Reference yield:

: 140659-43-4
[1S-(1β,4β,7aβ)]-[1R-(3aα)]-octahydro-1-acetyl-4-[(tert-butyldimethylsilyl)oxy]-7a-methyl-1H-indene

: 627461-25-0
(1S,3aS,7aS)-1-(5-Methoxymethoxy-5-methyl-hexa-1,3-diynyl)-7a-methyl-4-[2-[(3S,5R)-2-methylene-3,5-bis-triisopropylsilanyloxy-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-octahydro-indene

Guidance literature:: Multi-step reaction with 6 steps

1.1: 64 percent / LDA / tetrahydrofuran; hexane / 1 h / -78 - 20 °C

2.1: 98 percent / tetrahydrofuran; hexane / 1 h / 20 °C

3.1: 86 percent / n-HexLi; I₂ / hexane; tetrahydrofuran / 0.25 h / -78 °C

4.1: 88 percent / CuI; pyrrolidine / 1 h / 20 °C

5.1: HF / 2 h / 20 °C

5.2: 99 percent / pyridinium dichromate / CH₂Cl₂ / 4 h / 20 °C

6.1: 80 percent / n-BuLi / hexane; tetrahydrofuran / -78 - -40 °C

With pyrrolidine; copper(l) iodide; n-butyllithium; hydrogen fluoride; iodine; n-hexyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane; 6.1: Wittig-Horner coupling;
DOI:10.1021/ol0351246