pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate

Base Information

• Chemical Name: pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate
• CAS No.: 1254692-11-9
• Molecular Formula: C₁₄H₂₁BN₂O₆S
• Molecular Weight: 356.208
• Mol file: 1254692-11-9.mol

Synonyms:pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate

Chemical Property of pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate

There total 2 articles about pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

→ pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate (1254692-11-9)

Guidance literature:

With methanol; In tetrahydrofuran; at -10 - 20 ℃; for 1.16667h; Inert atmosphere;

In tetrahydrofuran; at -10 - 20 ℃; Inert atmosphere;

Reference yield:

pinacol aminomethylboronate (298689-75-5) + (3-nitrophenyl)methanesulfonyl chloride (58032-84-1) → pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate (1254692-11-9)

Guidance literature:

In tetrahydrofuran; methanol; at -10 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm101015z

Reference yield: 90.0%

pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate (1254692-11-9) → pinacol (3-aminophenylmethanesulfonylamino)methaneboronate hydrochloride (1254692-12-0)

Guidance literature:

pinacol (3-nitrophenylmethanesulfonylamino)methaneboronate; With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 16h;

With hydrogenchloride; In methanol; for 0.75h;

DOI:10.1021/jm101015z

upstream raw materials:

pinacol aminomethylboronate

(3-nitrophenyl)methanesulfonyl chloride

Downstream raw materials:

pinacol (3-aminophenylmethanesulfonylamino)methaneboronate hydrochloride

Refernces

• 1、 Eidam, Oliv,Romagnoli, Chiara,Caselli, Emilia,Babaoglu, Kerim,Pohlhaus, Denise Teotico,Karpiak, Joel,Bonnet, Richard,Shoichet, Brian K.,Prati, Fabio. "Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids as β-lactamase inhibitors". experimental part. p. 7852 - 7863. Retrieved 2011/02/23.