N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide
CAS No.:1425942-91-1
Molecular Formula:C₂₃H₁₉Cl₃F₃NO₂
Molecular Weight:504.764
Hs Code.:

Synonyms:N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

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Chemical Property of N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

Chemical Property:

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Technology Process of N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

There total 8 articles about N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425943-08-3
(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethanamine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1425942-90-0
N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

: 1425942-91-1
N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Overall yield = 4.3 g; Inert atmosphere;

Reference yield:

: C₂₇H₁₉Cl₃F₃NO₄

: 1425942-90-0
N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

: 1425942-91-1
N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / hexane / 6 h / 37503.8 Torr / Reflux

2: hydrazine hydrate / ethanol / 50 °C

3: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In ethanol; hexane; dichloromethane;

Reference yield:

: 36244-78-7
2-[(1S)-1-(4-bromophenyl)ethyl]isoindoline-1,3-dione

: 1425942-90-0
N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

: 1425942-91-1
N-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); sodium acetate / N,N-dimethyl acetamide / 0.5 h / 175 - 200 °C / Inert atmosphere; Microwave irradiation

2: dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen / toluene / 16 h / 100 °C / 37503.8 Torr

3: toluene-4-sulfonic acid / hexane / 6 h / 37503.8 Torr / Reflux

4: hydrazine hydrate / ethanol / 50 °C

5: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; sodium acetate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In ethanol; hexane; dichloromethane; N,N-dimethyl acetamide; toluene;