2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one

Base Information

• Chemical Name: 2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one
• CAS No.: 1224712-93-9
• Molecular Formula: C₂₁H₁₅ClO₃
• Molecular Weight: 350.801
• Mol file: 1224712-93-9.mol

Synonyms:2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one

Chemical Property of 2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one

There total 4 articles about 2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(prop-2-ynyloxy)-1-naphthaldehyde (58758-48-8) + 4-chlorobenzaldehyde (104-88-1) → 2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one (1224712-93-9)

Guidance literature:

With C₉H₁₄NO₂S₂⁽¹⁺⁾*ClO₄^(1-); potassium carbonate; In tetrahydrofuran; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja102130s

Reference yield:

2-(prop-2-ynyloxy)-1-naphthaldehyde (58758-48-8) + 4-chlorobenzaldehyde (104-88-1) → 2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one (1224712-93-9) + 2-(2-(4-chlorophenyl)-2-oxoethyl)-2-methylnaphtho[2,1-b]furan-1(2H)-one (1334472-92-2)

Guidance literature:

With 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; potassium carbonate; In tetrahydrofuran; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol2023483

Reference yield:

2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2,3-dihydro-benzo[f]chromen-1-one (1224712-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide; toluene / 15 h / 20 °C / Inert atmosphere

2: 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; triethylamine / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

With 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol2023483

upstream raw materials:

2-(prop-2-ynyloxy)-1-naphthaldehyde

4-chlorobenzaldehyde

2-hydroxynaphthalene-1-carbaldehyde