Technology Process of 5-benzyl-2',3'-dideoxyuridine
There total 5 articles about 5-benzyl-2',3'-dideoxyuridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; potassium carbonate;
palladium on activated charcoal;
In
ethanol;
under 760 Torr;
DOI:10.1002/jhet.5570270609
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) hexamethyldisilazane, (NH4)2SO4 / 1.) reflux, 3 h, 2.) acetonitrile, reflux, 4 h
2: 86 percent / KOH / methanol / 3 h / Ambient temperature
3: 67 percent / 2-chloro-1,1,2-trifluorotriethylamine / CH2Cl2 / 3 h / Ambient temperature
4: 68 percent / hydrogen bromide / dimethylformamide / 0.25 h / 85 °C
5: 79 percent / H2, K2CO3 / 5percent Pd/C / ethanol / 760 Torr
With
N-(2-chloro-1,1,2-trifluoroethyl)diethylamine; ammonium sulfate; potassium hydroxide; hydrogen bromide; hydrogen; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270609
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) hexamethyldisilazane, (NH4)2SO4 / 1.) reflux, 3 h, 2.) acetonitrile, reflux, 4 h
2: 86 percent / KOH / methanol / 3 h / Ambient temperature
3: 67 percent / 2-chloro-1,1,2-trifluorotriethylamine / CH2Cl2 / 3 h / Ambient temperature
4: 68 percent / hydrogen bromide / dimethylformamide / 0.25 h / 85 °C
5: 79 percent / H2, K2CO3 / 5percent Pd/C / ethanol / 760 Torr
With
N-(2-chloro-1,1,2-trifluoroethyl)diethylamine; ammonium sulfate; potassium hydroxide; hydrogen bromide; hydrogen; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270609
