(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester
CAS No.:96895-74-8
Molecular Formula:C₁₈H₂₃F₃O₄
Molecular Weight:360.373
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester

There total 7 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 96856-99-4
(2S,3S)-(+)-1,2-epoxy-3-octanol

: 96895-74-8
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201600637

Reference yield:

: 3391-86-4
1-octen-3-ol

: 96895-74-8
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83.5 percent / Ti(i-PrO)4, diisopropyl D-(-)-tartrate, t-BuOOH / CH₂Cl₂ / 14.5 h / -20 °C / op: 93.6percent

2: 87.7 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / 15 h / Ambient temperature; opt. pur. of start mat: 93.6percent

3: 78.9 percent / 1N KOH / tetrahydrofuran; methanol / 1.) 10 min; 0 deg C, 2.) RT, 30 min; op: 92percent

With titanium(IV) isopropylate; tert.-butylhydroperoxide; potassium hydroxide; D-(-)-diisopropyl tartrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)96499-3

Reference yield:

: 89408-81-1,96856-99-4,98897-19-9,127996-51-4,127996-52-5,135637-52-4,135637-53-5,96856-96-1
(1R)-1-[(2S)-oxiran-2-yl]hexan-1-ol

: 96895-74-8
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-(S)-1-oxiranyl-hexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87.7 percent / diethylazodicarboxylate, PPh₃ / tetrahydrofuran / 15 h / Ambient temperature; opt. pur. of start mat: 93.6percent

2: 78.9 percent / 1N KOH / tetrahydrofuran; methanol / 1.) 10 min; 0 deg C, 2.) RT, 30 min; op: 92percent

With potassium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(01)96499-3