3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole

Base Information

Chemical Name:3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole
CAS No.:719288-31-0
Molecular Formula:C₃₀H₃₁N₅O₄
Molecular Weight:525.607
Hs Code.:

Synonyms:3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole

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Chemical Property of 3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole

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Technology Process of 3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole

There total 8 articles about 3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1374846-34-0
4-[1-(4-acetylamino-2-benzyloxy-benzoyl)-2-dimethylamino-vinyl]-piperazine-1-carboxylic acid benzyl ester

: 719288-31-0
3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole

Guidance literature:: With methanol; hydrazine; at 20 ℃; for 72h;

Reference yield:

: 719288-29-6
N-[3-benzyloxy-4-(2,2-dibromo-acetyl)-phenyl]-acetamide

: 719288-31-0
3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: Diethyl phosphonate; triethylamine / tetrahydrofuran / 2 h / 20 °C

2.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

3.1: tetrahydrofuran / 1.08 h / 120 °C / Microwave

3.2: 0.67 h / 120 °C / Microwave

4.1: methanol; hydrazine / 72 h / 20 °C

With methanol; Diethyl phosphonate; potassium carbonate; triethylamine; hydrazine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);

Reference yield:

: 719288-28-5
N-(4-acetyl-3-benzyloxy-phenyl)-acetamide

: 719288-31-0
3-[4-acetamido-2-benzyloxyphenyl]-4-[4-(benzyloxycarbonyl)piperazin-1-yl]-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: phenyl-trimethyl-ammonium perbromide / tetrahydrofuran / 2 h / 20 °C

2.1: Diethyl phosphonate; triethylamine / tetrahydrofuran / 2 h / 20 °C

3.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

4.1: tetrahydrofuran / 1.08 h / 120 °C / Microwave

4.2: 0.67 h / 120 °C / Microwave

5.1: methanol; hydrazine / 72 h / 20 °C

With methanol; phenyl-trimethyl-ammonium perbromide; Diethyl phosphonate; potassium carbonate; triethylamine; hydrazine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);