(2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid

Base Information

Chemical Name:(2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid
CAS No.:131066-45-0
Molecular Formula:C₁₇H₂₆NO₆P
Molecular Weight:371.37
Hs Code.:

Synonyms:(2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid

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Chemical Property of (2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid

Chemical Property:

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Technology Process of (2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid

There total 4 articles about (2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 131066-44-9,131102-85-7
methyl 2-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanoate

: 131102-84-6
(2S)-2-<<<<(N-benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>methyl>-4-methylpentanoic acid

: 131066-45-0
(2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid

Guidance literature:: With borate buffer; for 24h; subtilisin Carlsberg (protease IV);
DOI:10.1021/ja00001a043

Reference yield:

: 3070-69-7
methyl 2-(2-methylpropyl)acrylate

: 131066-45-0
(2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

With borate buffer; bis-(trimethylsilyl)acetamide; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-43-8
N-benzyloxycarbonylaminomethyl-H-phosphinic acid

: 131066-45-0
(2S)-2-<<<(N-carbobenzoxyamino)methyl>hydroxyphosphinyl>methyl>-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

With borate buffer; bis-(trimethylsilyl)acetamide; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043