4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

Base Information

Chemical Name:4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole
CAS No.:1607441-86-0
Molecular Formula:C₁₈H₁₃F₆N₃O₂
Molecular Weight:417.311
Hs Code.:

Synonyms:4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

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Chemical Property of 4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

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Technology Process of 4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

There total 7 articles about 4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607442-71-6
4-(bromomethyl)-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

: 917-54-4
methyllithium

: 1607441-86-0
4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

Guidance literature:: With copper(l) cyanide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1607442-67-0
ethyl 5-[3-(trifluoromethoxy)phenoxy]-2H-1,2,3-triazole-4-carboxylate

: 1607441-86-0
4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

2.1: sodium dithionite / water; acetonitrile / 2 h / 23 °C

3.1: sulfuric acid; isopentyl nitrite / ethanol / 1 h / -20 °C

3.2: 14 h / 23 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C

5.1: acetic acid; hydrogen bromide / water / 4 h / Reflux

6.1: copper(l) cyanide / diethyl ether; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium dithionite; sulfuric acid; hydrogen bromide; copper(l) cyanide; potassium carbonate; acetic acid; isopentyl nitrite; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 1607441-86-0
4-ethyl-5-[3-(trifluoromethoxy)phenoxy]-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

2.1: sodium dithionite / water; acetonitrile / 2 h / 23 °C

3.1: sulfuric acid; isopentyl nitrite / ethanol / 1 h / -20 °C

3.2: 14 h / 23 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C

5.1: acetic acid; hydrogen bromide / water / 4 h / Reflux

6.1: copper(l) cyanide / diethyl ether; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium dithionite; sulfuric acid; hydrogen bromide; copper(l) cyanide; potassium carbonate; acetic acid; isopentyl nitrite; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetonitrile;