Technology Process of (3aS,4R,8aS)-4-Benzyloxymethyl-2,2-dimethyl-3a,4,6,8a-tetrahydro-[1,3]dioxolo[4,5-c]oxepine
There total 5 articles about (3aS,4R,8aS)-4-Benzyloxymethyl-2,2-dimethyl-3a,4,6,8a-tetrahydro-[1,3]dioxolo[4,5-c]oxepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triflic acid / CH2Cl2
2: DIBALH / toluene / -78 °C
3: tetrahydrofuran
4: KN(TMS)2 / tetrahydrofuran
5: 97 percent / (Cy3P)2Ru(Cl)2=CHPh / benzene / 20 °C
With
Grubbs catalyst first generation; trifluorormethanesulfonic acid; potassium hexamethylsilazane; diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane; toluene; benzene;
1: benzylation / 2: Reduction / 3: Wittig reaction / 4: Alkylation / 5: ring closing metathesis;
DOI:10.1016/S0040-4039(99)01881-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: DIBALH / toluene / -78 °C
2: tetrahydrofuran
3: KN(TMS)2 / tetrahydrofuran
4: 97 percent / (Cy3P)2Ru(Cl)2=CHPh / benzene / 20 °C
With
Grubbs catalyst first generation; potassium hexamethylsilazane; diisobutylaluminium hydride;
In
tetrahydrofuran; toluene; benzene;
1: Reduction / 2: Wittig reaction / 3: Alkylation / 4: ring closing metathesis;
DOI:10.1016/S0040-4039(99)01881-X
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrahydrofuran
2: KN(TMS)2 / tetrahydrofuran
3: 97 percent / (Cy3P)2Ru(Cl)2=CHPh / benzene / 20 °C
With
Grubbs catalyst first generation; potassium hexamethylsilazane;
In
tetrahydrofuran; benzene;
1: Wittig reaction / 2: Alkylation / 3: ring closing metathesis;
DOI:10.1016/S0040-4039(99)01881-X
