[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

Base Information

Chemical Name:[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol
CAS No.:845439-81-8
Molecular Formula:C₄₁H₆₁NO₄SSi₂
Molecular Weight:720.177
Hs Code.:

[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10<i>H</i>-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

Synonyms:[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

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Chemical Property of [2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

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Technology Process of [2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

There total 13 articles about [2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26116-47-2
4-(2-tetrahydro-1H-1-pyrrolylethoxy)benzaldehyde

: 845439-63-6
2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthrene

: 845439-90-9
[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

: [2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

: [2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

: 845439-81-8
[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ol047741f

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 845439-81-8
[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / boron tribromide / 20 °C

2: LAH / tetrahydrofuran / 0 °C

3: TFA; Et₃SiH

4: 100 percent / Et₃N

5: sec-BuLi / tetrahydrofuran / -78 °C

With triethylsilane; lithium aluminium tetrahydride; sec.-butyllithium; boron tribromide; triethylamine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/ol047741f

Reference yield:

: 108-46-3
recorcinol

: 845439-81-8
[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 12 steps

1.1: CuSO₄; NaOH

1.2: 100 percent / Cs₂CO₃

2.1: 90 percent / Me₃Al / 80 °C

3.1: 75 percent / NaH; DMAP

4.1: 75 percent / diphenyl ether / 4 h / 280 °C

5.1: NaOH / methanol

5.2: 100 percent / aq. HCl

6.1: boron tribromide / 0 °C

7.1: 80 percent / boron tribromide / 20 °C

8.1: LAH / tetrahydrofuran / 0 °C

9.1: TFA; Et₃SiH

10.1: 100 percent / Et₃N

11.1: sec-BuLi / tetrahydrofuran / -78 °C

With triethylsilane; dmap; sodium hydroxide; lithium aluminium tetrahydride; trimethylaluminum; sec.-butyllithium; boron tribromide; sodium hydride; copper(II) sulfate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diphenylether; 4.1: Newman-Kwart rearrangement;
DOI:10.1021/ol047741f