2-Methyl-6-thioxo-5-(triphenyl-λ⁵-phosphanylidene)-5,6-dihydro-3H-pyrimidin-4-one

Base Information

• Chemical Name: 2-Methyl-6-thioxo-5-(triphenyl-λ⁵-phosphanylidene)-5,6-dihydro-3H-pyrimidin-4-one
• CAS No.: 155787-01-2
• Molecular Formula: C₂₃H₁₉N₂OPS
• Molecular Weight: 402.456

Synonyms:2-Methyl-6-thioxo-5-(triphenyl-λ⁵-phosphanylidene)-5,6-dihydro-3H-pyrimidin-4-one

Chemical Property of 2-Methyl-6-thioxo-5-(triphenyl-λ⁵-phosphanylidene)-5,6-dihydro-3H-pyrimidin-4-one

Chemical Property:

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Technology Process of 2-Methyl-6-thioxo-5-(triphenyl-λ⁵-phosphanylidene)-5,6-dihydro-3H-pyrimidin-4-one

There total 5 articles about 2-Methyl-6-thioxo-5-(triphenyl-λ⁵-phosphanylidene)-5,6-dihydro-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4-Mercapto-2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-triphenyl-phosphonium; chloride → 2-Methyl-6-thioxo-5-(triphenyl-λ5-phosphanylidene)-5,6-dihydro-3H-pyrimidin-4-one (155787-01-2)

Guidance literature:

With triethylamine; In methanol; at 20 - 25 ℃; for 4h;

Reference yield:

(4-Mercapto-2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-triphenyl-phosphonium; chloride → 2-Methyl-6-thioxo-5-(triphenyl-λ5-phosphanylidene)-5,6-dihydro-1H-pyrimidin-4-one (155787-01-2)

Guidance literature:

With triethylamine; In methanol; at 20 - 25 ℃; for 4h; Yield given;

DOI:10.1016/0040-4020(96)00425-5

Reference yield:

2-acetylamino-1-cyano-2-thioxoethylidenotriphenyl phosphorane (155786-92-8) → 2-Methyl-6-thioxo-5-(triphenyl-λ5-phosphanylidene)-5,6-dihydro-1H-pyrimidin-4-one (155787-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 36percent HCl / methanol / 5 h / 20 - 25 °C

2: triethylamine / methanol / 4 h / 20 - 25 °C

With hydrogenchloride; triethylamine; In methanol;

DOI:10.1016/0040-4020(96)00425-5

upstream raw materials:

2-acetylamino-1-cyano-2-thioxoethylidenotriphenyl phosphorane

cyanomethylene triphenylphosphorane

Downstream raw materials:

2-Methyl-6-methylsulfanyl-5-(triphenyl-λ⁵-phosphanylidene)-5H-pyrimidin-4-one

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