4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde

Base Information

Chemical Name:4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde
CAS No.:668480-90-8
Molecular Formula:C₂₃H₁₆F₃NO₂S
Molecular Weight:427.447
Hs Code.:

Synonyms:4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde

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Chemical Property of 4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde

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Technology Process of 4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde

There total 1 articles about 4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7770-45-8
4-hydroxy-1-naphthaldehyde

: 317318-97-1
5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 668480-90-8
4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde

Guidance literature:: With caesium carbonate; In acetone; at 20 - 35 ℃; for 5h;

Reference yield:

: 668480-90-8
4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde

: 3938-96-3
ethyl 2-methoxyacetate

: 668480-91-9
3-hydroxy-2-methoxy-3-{4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalen-1-yl}-propionic acid ethyl ester

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -10 ℃;

ethyl 2-methoxyacetate; In tetrahydrofuran; hexane; at -75 ℃; for 0.5h;

4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde; In tetrahydrofuran; hexane; at -75 ℃; for 0.5h;

Reference yield:

: 668480-90-8
4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalene-1-carbaldehyde

: 2-methoxy-3-{4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-naphthalen-1-yl}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -10 °C

1.2: 0.5 h / -75 °C

1.3: 0.5 h / -75 °C

2.1: triethylsilane; trifluoroacetic acid / 3 h / 0 °C

3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 1 h / 20 °C

With triethylsilane; sodium hydroxide; n-butyllithium; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; water;