3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride

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Chemical Name:3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride
CAS No.:1373758-71-4
Molecular Formula:C₂₀H₂₀BrCl₂N₅O*ClH
Molecular Weight:533.683
Hs Code.:

Synonyms:3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride

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Chemical Property of 3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride

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Technology Process of 3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride

There total 5 articles about 3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1373758-67-8
3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

: 1373758-71-4
3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;
DOI:10.1002/cjoc.201180295

Reference yield:

: 20776-67-4
2-amino-5-chloro-3-methylbenzoic acid

: 1373758-71-4
3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: ethanol / 2 h / 20 °C

4.2: 2 h

5.1: hydrogenchloride / diethyl ether

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1002/cjoc.201180295

Reference yield:

: 1373758-65-6
3-bromo-N-(4-chloro-2-formyl-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

: 1373758-71-4
3-bromo-N-(4-chloro-2-((isopropylamino)methyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 20 °C

1.2: 2 h

2.1: hydrogenchloride / diethyl ether

With hydrogenchloride; In diethyl ether; ethanol;
DOI:10.1002/cjoc.201180295