N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide

Base Information

• Chemical Name: N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide
• CAS No.: 299953-55-2
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• Mol file: 299953-55-2.mol

Synonyms:N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide

Chemical Property of N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide

There total 1 articles about N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

salicylaldehyde (90-02-8) + ibuprofen hydrazide (127222-69-9) → N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide (299953-55-2)

Guidance literature:

With acetic acid; In ethanol; for 1h; Reflux;

DOI:10.1055/s-0037-1611823

Reference yield:

N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide (299953-55-2) → N-butyl-N’-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / Reflux

2: potassium carbonate; sulfuric acid dibutyl ester / tetrahydrofuran / Reflux

With sulfuric acid dibutyl ester; potassium carbonate; In tetrahydrofuran;

DOI:10.1055/s-0037-1611823

Reference yield:

N-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide (299953-55-2) → N-benzyl-N’-2-hydroxybenzylidene-2-[4-(2-methylpropyl)phenyl]propane hydrazide

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / Reflux

2: benzyl chloride; potassium carbonate / tetrahydrofuran / Reflux

With potassium carbonate; benzyl chloride; In tetrahydrofuran;

DOI:10.1055/s-0037-1611823

upstream raw materials:

salicylaldehyde

ibuprofen hydrazide