(2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester

Base Information

Chemical Name:(2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester
CAS No.:920509-69-9
Molecular Formula:C₂₀H₂₀Cl₂N₆O₅
Molecular Weight:495.322
Hs Code.:

Synonyms:(2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester

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Chemical Property of (2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester

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Technology Process of (2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester

There total 7 articles about (2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 920509-68-8
6-(4-amino-2,6-dichlorophenoxy)-4-isopropyl-2-methyl-2H-pyridazin-3-one

: 68168-42-3
N-cyanoacetylurethane

: 920509-69-9
(2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester

Guidance literature:: 6-(4-amino-2,6-dichlorophenoxy)-4-isopropyl-2-methyl-2H-pyridazin-3-one; With hydrogenchloride; sodium nitrate; acetic acid; In water; at 5 - 10 ℃; for 0.5h;

N-cyanoacetylurethane; With sodium acetate; In water; at 5 - 10 ℃; for 0.5h;
DOI:10.1021/jm4019299

Reference yield:

: C₂₁H₁₄Cl₃N₃O₃

: 920509-69-9
(2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sodium acetate / 6 h / 120 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

3.1: N-butylamine / methanol / Reflux; Inert atmosphere

4.1: sodium nitrate; acetic acid; hydrogenchloride / water / 0.5 h / 5 - 10 °C

4.2: 0.5 h / 5 - 10 °C

With hydrogenchloride; sodium nitrate; sodium acetate; acetic acid; N-butylamine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4019299

Reference yield:

: 920509-67-7
2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)isoindoline-1,3-dione

: 920509-69-9
(2-cyano-2-{[3,5-dichloro-4-(5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]hydrazono}acetyl)carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-butylamine / methanol / Reflux; Inert atmosphere

2.1: sodium nitrate; acetic acid; hydrogenchloride / water / 0.5 h / 5 - 10 °C

2.2: 0.5 h / 5 - 10 °C

With hydrogenchloride; sodium nitrate; acetic acid; N-butylamine; In methanol; water;
DOI:10.1021/jm4019299