1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine

Base Information

Chemical Name:1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine
CAS No.:180997-82-4
Molecular Formula:C₁₉H₂₂N₄O₉
Molecular Weight:450.405
Hs Code.:

Synonyms:1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine

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Chemical Property of 1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine

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Technology Process of 1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine

There total 1 articles about 1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 88091-70-7
1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride

: 1-((2R,3S,4S,5R)-3-Amino-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione; hydrochloride

: 180997-82-4
1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine

Guidance literature:: With dmap; 4 A molecular sieve; In N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1002/hlca.19960790415

Reference yield: 89.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 180997-82-4
1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine

: [(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: In pyridine; for 24h; Ambient temperature;
DOI:10.1002/hlca.19960790415

Reference yield:

: 180997-82-4
1-{2-deoxy-2-[2-(4-nitrophenyl)ethoxycarbonylamino]-β-D-arabinofuranosyl}thymine

: [(2R,3S,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / pyridine / 24 h / Ambient temperature

2: 85 percent / 1H-tetrazole / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-tetrazole; In pyridine; dichloromethane;
DOI:10.1002/hlca.19960790415