8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole

Base Information

• Chemical Name: 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole
• CAS No.: 145100-72-7
• Molecular Formula: C₂₃H₂₆N₂
• Molecular Weight: 330.473
• Mol file: 145100-72-7.mol

Synonyms:8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole

Chemical Property of 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole

Chemical Property:

Purity/Quality:

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Technology Process of 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole

There total 3 articles about 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

8-Methyl-3-(1-phenyl-ethyl)-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazol-3-ium; bromide → 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole (145100-72-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; water;

DOI:10.1002/hlca.19980810307

Reference yield:

8-Methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole; hydrochloride (73166-21-9) → 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole (145100-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: various solvent(s) / Heating

2: 75 percent / NaBH₄ / methanol; H₂O

With sodium tetrahydroborate; In methanol; water;

DOI:10.1002/hlca.19980810307

Reference yield:

1,2-bis-tosyloxyethane (6315-52-2) + (+/-)-6-methyl-1-<(S)-1-phenylethylamino>-1,2,3,4-tetrahydrocarbazole (118498-99-0) → 8-Methyl-3-(1-phenyl-ethyl)-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole (145100-72-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMSO, RT, 2 h, 2.) DMSO, 2.5 h;

DOI:10.1007/BF00772896

upstream raw materials:

1,2-bis-tosyloxyethane

(+/-)-6-methyl-1-<(S)-1-phenylethylamino>-1,2,3,4-tetrahydrocarbazole

8-Methyl-2,4,5,6-tetrahydro-1H-pyrazino[3,2,1-jk]carbazole; hydrochloride

Downstream raw materials:

2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino(3,2,1-jk)carbazole monohydrochloride

(S)-8-Methyl-1,2,3a,4,5,6-hexahydro-pyrazino[3,2,1-jk]carbazole-3-carboxylic acid ((R)-1-phenyl-ethyl)-amide

(R)-8-Methyl-1,2,3a,4,5,6-hexahydro-pyrazino[3,2,1-jk]carbazole-3-carboxylic acid ((R)-1-phenyl-ethyl)-amide

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