ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate

Base Information

• Chemical Name: ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate
• CAS No.: 108350-05-6
• Molecular Formula: C₁₉H₂₈O₃Si
• Molecular Weight: 332.515
• Mol file: 108350-05-6.mol

Synonyms:ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate

Chemical Property of ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate

There total 1 articles about ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-phenylacetoacetate (5413-05-8) + 3-trimethylsilyl-2-(methylsulphonyloxymethyl)prop-1-ene (74532-54-0) → ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate (108350-05-6)

Guidance literature:

With sodium hydride; Multistep reaction;

DOI:10.1016/S0040-4039(00)84729-2

Reference yield: 73.0%

ethyl 2-acetyl-2-phenyl-4-(trimethylsilyl)methyl-4-pentenoate (108350-05-6) → ethyl (1R*, 2R*)-1-phenyl-2-methyl-2-hydroxy-4-methylenecyclopentanecarboxylate (105665-75-6)

Guidance literature:

titanium tetrachloride; In dichloromethane; at -78 ℃; for 2h;

DOI:10.1016/S0040-4039(00)84729-2

upstream raw materials:

ethyl 2-phenylacetoacetate

3-trimethylsilyl-2-(methylsulphonyloxymethyl)prop-1-ene

Downstream raw materials:

ethyl (1R^*, 2R^*)-1-phenyl-2-methyl-2-hydroxy-4-methylenecyclopentanecarboxylate