2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

Base Information

Chemical Name:2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone
CAS No.:1447726-61-5
Molecular Formula:C₂₅H₂₄FN₇O
Molecular Weight:457.51
Hs Code.:

Synonyms:2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

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Chemical Property of 2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

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Technology Process of 2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

There total 3 articles about 2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447727-54-9
2-(3-bromo-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

: 139911-27-6
4-fluoro-3-methylphenyl boronic acid

: 1447726-61-5
2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; at 120 ℃; Inert atmosphere;

Reference yield:

: 20980-22-7
N-(2-pyridinyl)piperazine

: 1447726-61-5
2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: potassium carbonate / acetone / 20 °C

3: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; acetone;

Reference yield:

: 4922-98-9
3-phenyl-1H-1,2,4-triazol-5-amine

: 1447726-61-5
2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium nitrite; hydrogen bromide / 0.33 h / -5 - 20 °C / Reflux

2: potassium carbonate / acetone / 20 °C

3: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; sodium nitrite; In 1,4-dioxane; acetone;