(1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol

Base Information

Chemical Name:(1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol
CAS No.:1526936-57-1
Molecular Formula:C₁₃H₁₆F₃NO
Molecular Weight:259.271
Hs Code.:

Synonyms:(1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol

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Technology Process of (1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol

There total 5 articles about (1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1526936-85-5
(3S,3aR,6aR)-4,4-difluoro-3-(2-fluorophenyl)-3-methylhexahydrocyclopenta[d]isoxazole

: 1526936-57-1
(1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In ethanol; at 22 ℃; for 2.5h;

Reference yield:

: 59919-43-6,119458-73-0
rac-(3aR,6aR)-3-methyl-3a,5,6,6a-tetrahydrocyclopenta[d]isoxazol-4-one

: 1526936-57-1
(1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: morpholinosulfur trifluoride / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1.17 h / 70 - 78 °C / Inert atmosphere

2.2: 2.17 h / 70 - 78 °C

3.1: n-heptane; ethanol / Resolution of racemate

4.1: palladium 10% on activated carbon; ammonium formate / ethanol / 2.5 h / 22 °C

With n-butyllithium; palladium 10% on activated carbon; ammonium formate; morpholinosulfur trifluoride; In tetrahydrofuran; ethanol; hexane; n-heptane; dichloromethane; toluene;

Reference yield:

: rac-(3aR,6aR)-4,4-difluoro-3-methyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazol

: 1526936-57-1
(1R,2R)-2-[(S)-1-amino-1-(2-fluorophenyl)ethyl]-3,3-difluorocyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 1.17 h / 70 - 78 °C / Inert atmosphere

1.2: 2.17 h / 70 - 78 °C

2.1: n-heptane; ethanol / Resolution of racemate

3.1: palladium 10% on activated carbon; ammonium formate / ethanol / 2.5 h / 22 °C

With n-butyllithium; palladium 10% on activated carbon; ammonium formate; In tetrahydrofuran; ethanol; hexane; n-heptane; toluene;