N₃-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N₁'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide

Base Information

• Chemical Name: N₃-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N₁'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide
• CAS No.: 1360586-88-4
• Molecular Formula: C₃₅H₄₀Cl₂N₈O₅
• Molecular Weight: 723.659

Synonyms:N₃-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N₁'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide

Chemical Property of N₃-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N₁'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide

Chemical Property:

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Technology Process of N₃-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N₁'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide

There total 4 articles about N₃-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N₁'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-1,3'-bipyrrolidine-3-carboxamide (1360586-86-2) + methyl isocyanate (624-83-9) → N3-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N1'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide (1360586-88-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

2-amino-N-(2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)-N-methylacetamide (1360587-51-4) → N3-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N1'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide (1360586-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.17 h / 0 °C

3: dichloromethane / 0.17 h / 20 °C

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1'-(tert-butoxycarbonyl)-[1,3'-bipyrrolidine]-3-carboxylic acid (1360587-65-0) → N3-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-N1'-methyl-1,3'-bipyrrolidine-1',3-dicarboxamide (1360586-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.17 h / 0 °C

3: dichloromethane / 0.17 h / 20 °C

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

N-(2-((2,4-dichloro-3-((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-1,3'-bipyrrolidine-3-carboxamide

methyl isocyanate

2-amino-N-(2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)-N-methylacetamide

1'-(tert-butoxycarbonyl)-[1,3'-bipyrrolidine]-3-carboxylic acid

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