(5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

Base Information

Chemical Name:(5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline
CAS No.:877463-64-4
Molecular Formula:C₁₉H₂₅NO₄
Molecular Weight:331.412
Hs Code.:

Synonyms:(5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

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Technology Process of (5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

There total 1 articles about (5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 87976-52-1
((2-nitroethoxy)methyl)benzene

: 135029-56-0
(2S)-1,2-O-cyclohexylidenebut-3-ene-1,2-diol

: 877463-64-4
(5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

: 877463-63-3
(5S)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

Guidance literature:: With 1,4-diisocyanatobenzene; triethylamine; In toluene; for 42h; Heating;
DOI:10.1021/jo0517388

Reference yield: 89.0%

: 877463-64-4
(5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

: 334999-23-4
(5R)-5-[(1R)-1,2-dihydroxyethyl]-3-benzyloxymethyl-4,5-dihydrooxazole

Guidance literature:: With acetic acid; In water; at 80 ℃;
DOI:10.1021/jo0517388

Reference yield:

: 877463-64-4
(5R)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline

: 877463-72-4
(2R,4R,5R)-3-benzyloxymethyl-4,5-dihydroxypiperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / acetic acid / H₂O / 80 °C

2: 85 percent / pyridine; SOCl₂ / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 0.34 g / RuCl₃; NaIO₄ / acetonitrile; H₂O / 0.83 h / 20 °C

4: 34 percent / sodium carbonate; hydrogen / Pd/C / methanol / 5 h / 20 °C

5: 86 percent / H₂SO₄ / dioxane; H₂O / 36 h / 50 °C

With pyridine; ruthenium trichloride; sodium periodate; thionyl chloride; sulfuric acid; hydrogen; sodium carbonate; acetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo0517388