trifluoroacetaldehyde (S)-SAMP hydrazone

Base Information

• Chemical Name: trifluoroacetaldehyde (S)-SAMP hydrazone
• CAS No.: 343614-53-9
• Molecular Formula: C₈H₁₃F₃N₂O
• Molecular Weight: 210.199
• Mol file: 343614-53-9.mol

Synonyms:trifluoroacetaldehyde (S)-SAMP hydrazone

Chemical Property of trifluoroacetaldehyde (S)-SAMP hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of trifluoroacetaldehyde (S)-SAMP hydrazone

There total 1 articles about trifluoroacetaldehyde (S)-SAMP hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) + ethyl trifluoroacetaldehyde hemiacetal (433-27-2) → trifluoroacetaldehyde (S)-SAMP hydrazone (343614-53-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 5h; Heating;

DOI:10.1021/ol015869g

Reference yield: 15.0%

phenyllithium (591-51-5) + trifluoroacetaldehyde (S)-SAMP hydrazone (343614-53-9) → ((S)-2-Methoxymethyl-pyrrolidin-1-yl)-((R)-2,2,2-trifluoro-1-phenyl-ethyl)-amine + ((S)-2-Methoxymethyl-pyrrolidin-1-yl)-((S)-2,2,2-trifluoro-1-phenyl-ethyl)-amine

Guidance literature:

In diethyl ether; hexane; at -78 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/ol015869g

Reference yield:

trifluoroacetaldehyde (S)-SAMP hydrazone (343614-53-9) → N-(2,2-dimethyl-1-trifluoromethyl-propyl)-N-(2-methoxymethyl-pyrrolidin-1-yl)-benzamide (343614-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / hexane; diethyl ether / 1 h / -78 °C

2: DMAP; Et₃N / -78 - 20 °C

With dmap; triethylamine; In diethyl ether; hexane;

DOI:10.1021/ol015869g

upstream raw materials:

(S)-1-amino-2-(methoxymethyl)pyrrolidine

ethyl trifluoroacetaldehyde hemiacetal

Downstream raw materials:

N-(2,2-dimethyl-1-trifluoromethyl-propyl)-N-(2-methoxymethyl-pyrrolidin-1-yl)-benzamide

N-(2-methoxymethyl-pyrrolidin-1-yl)-N-(1-trifluoromethyl-butyl)-benzamide

N-(2-methoxymethyl-pyrrolidin-1-yl)-N-(1-trifluoromethyl-pentyl)-benzamide

N-(2-methoxymethyl-pyrrolidin-1-yl)-N-(1-trifluoromethyl-heptyl)-benzamide