C₁₆H₁₁ClOS

Base Information

• Chemical Name: C₁₆H₁₁ClOS
• CAS No.: 1373520-40-1
• Molecular Formula: C₁₆H₁₁ClOS
• Molecular Weight: 286.782
• Mol file: 1373520-40-1.mol

Synonyms:C₁₆H₁₁ClOS

Chemical Property of C₁₆H₁₁ClOS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₆H₁₁ClOS

There total 1 articles about C₁₆H₁₁ClOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydro-4H-[1]benzothiopyran-4-one (3528-17-4) + 2-chloro-benzaldehyde (89-98-5) → C16H11ClOS (1373520-40-1)

Guidance literature:

With piperidine; In chloroform; for 5h; Reflux;

DOI:10.1080/17415993.2016.1149856

Reference yield: 86.0%

C16H11ClOS (1373520-40-1) + N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) → (2R,3S,3aR)-tert-butyl 3-(2-chlorophenyl)-2,3,3a,4-tetrahydrothiochromeno[4,3-b]pyrrole-2-carboxylate (1373520-35-4)

Guidance literature:

C₁₆H₁₁ClOS; N-(diphenylmethylene)glycine tert-butyl ester; With C₇₀H₄₀F₂₄NO⁽¹⁺⁾*Br^(1-); caesium carbonate; In toluene; at 15 ℃; for 96h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; toluene; at 0 ℃; for 6h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/jo300500r

Reference yield: 77.0%

C16H11ClOS (1373520-40-1) + malononitrile (109-77-3) → 2-amino-4-(2-chlorophenyl)-4,5-dihydrothiochromeno[4,3-b]pyran-3-carbonitrile

Guidance literature:

With magnesia; In ethanol; for 12h; Reflux;

DOI:10.1080/17415993.2016.1149856

upstream raw materials:

2,3-dihydro-4H-[1]benzothiopyran-4-one

2-chloro-benzaldehyde

Downstream raw materials:

(2R,3S,3aR)-tert-butyl 3-(2-chlorophenyl)-2,3,3a,4-tetrahydrothiochromeno[4,3-b]pyrrole-2-carboxylate