Technology Process of N-(4-cyano-2-methoxy-phenyl)-2-[3,3-dimethyl-but-(E)-ylideneamino]-acetamide
There total 6 articles about N-(4-cyano-2-methoxy-phenyl)-2-[3,3-dimethyl-but-(E)-ylideneamino]-acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-amino-N-(4-cyano-2-methoxyphenyl)acetamide trifluoroacetic acid;
With
triethylamine;
In
tert-butyl methyl ether;
at 20 ℃;
for 0.5h;
3,3-dimethylbutyrylaldehyde;
In
tert-butyl methyl ether;
at 20 ℃;
for 3.5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 2 h / Reflux
1.2: 72 h / 20 °C
2.1: pyridine; trifluoroacetic anhydride / 1,4-dioxane / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.75 h / 20 °C / 2585.81 Torr
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C
5.1: dichloromethane / 1 h / 20 °C
6.1: triethylamine / tert-butyl methyl ether / 0.5 h / 20 °C
6.2: 3.5 h / 20 °C
With
pyridine; thionyl chloride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride;
palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; tert-butyl methyl ether; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.75 h / 20 °C / 2585.81 Torr
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C
3.1: dichloromethane / 1 h / 20 °C
4.1: triethylamine / tert-butyl methyl ether / 0.5 h / 20 °C
4.2: 3.5 h / 20 °C
With
hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
dichloromethane; tert-butyl methyl ether; ethyl acetate;
