ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate
• CAS No.: 1357010-82-2
• Molecular Formula: C₂₂H₂₆N₂O₄
• Molecular Weight: 382.459
• Mol file: 1357010-82-2.mol

Synonyms:ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Chemical Property of ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

There total 1 articles about ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

Ethyl 1-amino-5-methyl-1H-pyrrole-3-carboxylate (941693-86-3) + C16H22O4 (1357010-76-4) → ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-82-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 36h; Reflux;

DOI:10.1016/j.bmc.2011.11.015

Reference yield: 99.0%

ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-82-2) → ethyl 4-chloro-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-88-8)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In tetrahydrofuran; for 2.5h; Reflux;

DOI:10.1016/j.bmc.2011.11.015

Reference yield:

ethyl 4-hydroxy-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-82-2) → ethyl 2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrachloromethane; triphenylphosphine / tetrahydrofuran / 2.5 h / Reflux

2: palladium 10% on activated carbon; ammonium formate / 1,4-dioxane; ethanol / 2 h / 20 °C / Inert atmosphere

With tetrachloromethane; palladium 10% on activated carbon; ammonium formate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol;

DOI:10.1016/j.bmc.2011.11.015

upstream raw materials:

Ethyl 1-amino-5-methyl-1H-pyrrole-3-carboxylate

C₁₆H₂₂O₄

Downstream raw materials:

ethyl 4-chloro-2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

ethyl 2-(4-ethoxy-2-ethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate