3-acetyl-6-amino>indole

Base Information

• Chemical Name: 3-acetyl-6-amino>indole
• CAS No.: 104447-60-1
• Molecular Formula: C₁₆H₁₈N₂O₃
• Molecular Weight: 286.331
• Mol file: 104447-60-1.mol

Synonyms:3-acetyl-6-amino>indole

Chemical Property of 3-acetyl-6-amino>indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetyl-6-amino>indole

There total 1 articles about 3-acetyl-6-amino>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-1H-indole (5318-27-4) → 3-acetyl-6-amino>indole (104447-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 1.) POCl₃, 2.) aq. NaOH / 1.) from 0 deg C to RT, 2.) 60 deg C, 30 min, 3.) reflux, 10 min

With sodium hydroxide; triethylamine; trichlorophosphate; In dichloromethane;

DOI:10.1021/jm00091a010

Reference yield: 78.0%

methyl 4-(bromomethyl)-3-methoxybenzoate (70264-94-7) + 3-acetyl-6-amino>indole (104447-60-1) → methyl 4-<<3-acetyl-6-amino>indol-1-yl>methyl>-3-methoxybenzoate (104447-61-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1021/jm00091a010

Reference yield:

3-acetyl-6-amino>indole (104447-60-1) → 4-(3-Acetyl-6-cyclopentyloxycarbonylamino-indol-1-ylmethyl)-3-methoxy-benzoic acid (104448-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 99 percent / aq. LiOH / methanol; tetrahydrofuran

With lithium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00091a010

upstream raw materials:

6-amino-1H-indole

Downstream raw materials:

methyl 4-<<3-acetyl-6-amino>indol-1-yl>methyl>-3-methoxybenzoate

4-(3-Acetyl-6-cyclopentyloxycarbonylamino-indol-1-ylmethyl)-3-methoxy-benzoic acid

[3-Acetyl-1-(4-benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indol-6-yl]-carbamic acid cyclopentyl ester